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Cramped chromatin regulator homolog 1 (CRAMP1)
- Target
- CRAMP1
- Molecular classification
- Chromatin-associated protein, Predicted chromatin-binding protein, Other (not a classic receptor, enzyme, transporter, or transcription factor)
01
Overview
Cramped chromatin regulator homolog 1 (CRAMP1) is a protein-coding gene highly conserved, with predicted functions in chromatin binding and nuclear pattern specification. Its molecular activity centers on possible regulation of gene expression through interactions with chromatin, though its specific functions in humans remain incompletely characterized. CRAMP1 is associated with developmental processes and has been implicated in rare syndromes such as alpha thalassemia-intellectual disability syndrome type 1. There is currently no evidence that CRAMP1 acts as a receptor, enzyme, or therapeutic target, and no drugs or biomarkers have been developed in relation to this gene. It is widely expressed across tissues, but its precise physiological and pathological roles require further clarification[1][2][5][6].
- Other names
- Cramped chromatin regulator 1CRAMP1Protein cramped-likeCRAMP1LHN1LC16orf34KIAA1426Cramped chromatin regulator homolog 1Hematological and neurological expressed 1-like proteinTCE4Crm, cramped-likeT-complex expressed gene 4
02
Biological functions
Chromatin bindingPattern specification process (predicted role)Nuclear localization (predicted activity)Potential regulation of gene expression (inferred from chromatin association)
03
Disease associations
Alpha thalassemia-intellectual disability syndrome type 1 (reported association)Other (no strong links established to cancer or other major disease categories)
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