Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Creatine Kinase B-type (CKB)
- Target
- CKB
- Molecular classification
- Enzyme
01
Overview
Creatine kinase B-type (CKB), also known as brain-type creatine kinase or CK-BB, is a cytosolic enzyme encoded by the CKB gene in humans. It plays a central role in cellular energy homeostasis and is involved in several physiological and pathological processes. CKB catalyzes the reversible transfer of phosphate groups between ATP and creatine or phosphocreatine (PCr) and ADP, regenerating ATP from ADP. It is critical for tissues with high fluctuating energy demands. Beyond its metabolic function, CKB regulates adaptive thermogenesis, suppresses ferroptosis, and inhibits epithelial-mesenchymal transition (EMT). Overexpression is observed in certain cancers, and it may regulate immune cell activation/development.
- Other names
- B-CKBCKCKBBCPK-BHEL-211HEL-S-29Brain-type creatine kinase
02
Biological functions
Energy metabolismATP regenerationAdaptive thermogenesisRegulation of ferroptosisRegulation of epithelial-mesenchymal transition (EMT)Regulation of immune cell activation/development
03
Disease associations
CancerProstate cancerColon cancer
04
Biomarkers
Elevated CKB levels in colon cancer
Beyond the preview
Go deeper on Creatine Kinase B-type (CKB).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Creatine Kinase B-type (CKB).