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Target intelligence / Profile preview
CREB binding protein (CBP)
- Target
- CBP
- Molecular classification
- Transcription factor, Histone modification, Enzyme (Histone Acetyltransferase), p300-CBP coactivator family
01
Overview
CREB binding protein (CBP), also known as CREBBP or KAT3A, is a transcriptional coactivator with intrinsic acetyltransferase activity. It regulates the activity of many genes involved in cell growth, division, and differentiation. CBP acetylates histones and transcription factors, altering chromatin structure and facilitating gene transcription. It interacts with transcription factors like CREB and plays a critical role in development, memory formation, and energy homeostasis. Dysfunction or mutation of CBP is implicated in Rubinstein-Taybi syndrome, various cancers, neurological disorders, diabetes, and metabolic regulation disorders.
- Other names
- CREBBPKAT3A
02
Mechanism of action
Acetylation of histones and transcription factors to promote gene expression.
03
Biological functions
Transcriptional coactivatorHistone acetylationTranscription initiationCell growthCell divisionCell differentiationMemory formationEnergy homeostasis
04
Disease associations
Rubinstein-Taybi syndromeCancerColorectal cancerHead and neck squamous cell carcinomaNeurological disordersAlzheimer's diseaseSchizophreniaDepressionDiabetesMetabolic regulation disorders
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