CREB-binding protein and E1A binding protein p300 (CBP and p300)

CREB-binding protein (CBP/CREBBP) and E1A binding protein p300 (p300/EP300) are highly conserved, ubiquitously expressed transcriptional coactivators with intrinsic histone acetyltransferase activity. They facilitate gene transcription by acetylating histones and transcription factors, thereby modulating chromatin accessibility and recruiting the transcriptional apparatus. Both proteins function as platforms for integrating multiple signaling pathways, including cAMP/PKA/CREB and NF-κB, which impact cell proliferation, differentiation, DNA repair, immune responses, metabolism, and stress adaptation. They play key roles in the etiologies of cancer, neurodegenerative diseases, and metabolic disorders, and have emerged as promising (but challenging) targets for epigenetic therapies.

Other names

CBPCREBBPKAT3ARSTSp300EP300

Inhibition of histone acetyltransferase activity (blockade of lysine acetylation on histones and transcription factors); modulation of transcriptional coactivation; altered chromatin accessibility and gene expression profiles; disruption of protein-protein interactions with transcription factors (e.g., CREB, β-catenin, NF-κB/p65).