CREB-regulated transcription coactivator 1 (CRTC1)

CREB-regulated transcription coactivator 1 (CRTC1) is a transcriptional coactivator that integrates multiple intracellular signals, notably cAMP and calcium, to regulate gene expression via its interaction with the cAMP response element-binding protein (CREB)[2][3][4]. It is primarily localized to the nucleus and cytosol, where its activity and localization are regulated by phosphorylation status in response to cellular energy and signaling cues. CRTC1 enhances CREB-mediated transcription, affecting processes like mitochondrial biogenesis, neuronal function, memory formation, and circadian regulation[3][2]. In cancer, CRTC1 can act as a driver when fused to MAML2, forming a potent oncogenic fusion transcript implicated in mucoepidermoid carcinoma[2][3]. Loss or dysregulation of CRTC1 activity is implicated in neurodegenerative diseases like Alzheimer's disease, underscoring its essential role in neural gene expression and survival[4].

Other names

TORC1Transducer of CREB protein 1KIAA0616MECT1WAMTP1Mucoepidermoid carcinoma translocated protein 1FLJ14027Transducer of regulated cAMP response element-binding protein 1MAML2 (fusion gene context)Mastermind-like protein 2 (fusion context)