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CREB regulated transcription coactivator 3 (CRTC3)

Target: CRTC3
Molecular classification: Transcription factor coactivator, Other: Protein coding gene

Overview

CREB regulated transcription coactivator 3 (CRTC3) is a protein coding gene encoding a transcriptional coactivator for CREB (cAMP response element binding protein). CRTC3 modulates CREB-dependent transcription by enabling activity independent of CREB phosphorylation and is active in the SIK/TORC signaling pathway. It is implicated in metabolic regulation, including mitochondrial biogenesis and catecholamine signaling in adipose tissue, and may selectively activate cAMP-responsive genes. CRTC3 has links to certain cancers through gene fusion events and is related to weight gain and metabolic disorders. Multiple transcript variants exist due to alternative splicing. Common aliases include TORC-3 and TORC3. Currently, CRTC3 is not known to be a direct drug target, biomarker, or safety concern from therapeutic intervention[1][2][3][4][7].

Other names: TORC-3TORC3CREB regulated transcription coactivator 3

Biological functions

Regulation of CREB-dependent gene transcriptionInduction of mitochondrial biogenesisRegulation of catecholamine signaling in adipose tissueRegulation of steroidogenic gene (e.g., StAR) expressionCoactivation of PPARGC1AEnhancement of CREB1/TAF4 interactionSupport of HTLV-1 LTR transcription via TAX coactivation in T-cells

Disease associations

Cancer (e.g., colorectal cancer, esophageal adenoid cystic carcinoma, mucoepidermoid carcinoma via fusion event)Metabolic regulation and obesity (CRTC3 involvement in weight gain)Other: Disorders involving cellular signaling and transcriptional dysregulation

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