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Target intelligence / Profile preview
CREB3 regulatory factor (CREBRF)
- Target
- CREBRF
- Molecular classification
- Transcription factor, DNA-binding protein
01
Overview
CREB3 regulatory factor (CREBRF) is a human gene encoding a transcription factor that acts as a negative regulator of the endoplasmic reticulum stress response, specifically suppressing the transcriptional activity of CREB3 during the unfolded protein response. It recruits CREB3 into nuclear foci and participates in protein catabolic regulation. Variants of CREBRF, such as rs373863828, have been linked to differences in body mass index and metabolic adaptation in certain human populations. As a nuclear, DNA-binding transcription factor, CREBRF is emerging as a potential target for research into metabolic diseases and cellular stress modulation.
- Other names
- CREBRFC5orf41LRF (Luman recruitment factor)adult retina proteinUPF0474 protein C5orf41luman/CREB3 recruitment factor
02
Mechanism of action
For hypothetical targeting, mechanisms would include modulation of transcriptional repression/activation, especially in UPR and catabolic processes.
03
Biological functions
Negative regulation of endoplasmic reticulum unfolded protein responseRepression of transcriptional activity of CREB3Regulation of protein catabolic processesNuclear recruitment of CREB3
04
Disease associations
Obesity and BMI regulation (variant rs373863828 is associated with body mass index changes in certain populations, such as Samoans)Potential metabolic disease (based on regulatory function in ER stress and metabolism)Other roles in cellular stress adaptation
05
Safety considerations
No specific safety concerns are documented yet, but as a transcriptional regulator of stress responses, targeting CREBRF could potentially affect cellular stress resilience and homeostasis.
06
Biomarkers
The missense variant rs373863828 in CREBRF serves as a biomarker for BMI changes, notably in Samoan populations
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