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Target intelligence / Profile preview
Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Precursor (CCHFV Glycoprotein Precursor)
- Target
- CCHFV Glycoprotein Precursor
- Molecular classification
- Viral glycoprotein, Polyprotein, Type I transmembrane protein
01
Overview
The glycoprotein precursor of the Crimean-Congo hemorrhagic fever virus (CCHFV) is encoded by the M segment of the viral genome. This large precursor protein undergoes complex posttranslational processing, generating mature glycoproteins Gn and Gc, which are essential for viral entry. Cleavage by furin produces GP38, a secreted glycoprotein involved in immune modulation. The glycoproteins are key targets for diagnostics and vaccine development.
- Other names
- CCHFV M segment polyproteinPreGnPreGcGn proteinGc proteinGP38GP85GP160
02
Mechanism of action
N/A
03
Biological functions
Viral entryHost cell attachmentMembrane fusionImmune modulationEliciting neutralizing antibodies
04
Disease associations
Crimean-Congo hemorrhagic fever (CCHF)Viral pathogenesisImmune evasion
05
Safety considerations
Potential for antibody-dependent enhancement (ADE)Glycosylation-dependent immunogenicity
06
Biomarkers
Antibodies against GnAntibodies against GcAntibodies against GP38
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