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Target intelligence / Profile preview
CRISPR-associated protein 3 (Cas3)
- Target
- Cas3
- Molecular classification
- Enzyme, Nuclease, Helicase, DNA-binding protein
01
Overview
Cas3 is a CRISPR-associated protein and a key component of the Type I CRISPR-Cas system. It functions as a DNA nuclease and helicase, responsible for degrading foreign DNA in prokaryotic cells. In genome editing applications, Cas3 is utilized to induce large, unidirectional deletions in target DNA.
- Other names
- CRISPR-Cas3 systemCascade-Cas3 complex
02
Mechanism of action
crRNA-guided DNA targeting and degradation via HD nuclease and SF2 helicase domains
03
Biological functions
Adaptive immunityDNA degradationGenome editingAntiviral defense
04
Disease associations
InfectionCancer (potential target for cancer cell targeting)Genetic disorders (potential therapeutic target)Viral infections (potential therapeutic target)
05
Safety considerations
Off-target effectsUnintended large-scale genomic deletionsImmune response to Cas3 protein
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