Target intelligence / Profile preview

CRISPR-associated protein 9 (Cas9)

Target: Cas9
Molecular classification: Endonuclease, Ribonucleoprotein complex component

Overview

CRISPR-associated protein 9 (Cas9) is an RNA-guided DNA endonuclease enzyme that plays a central role in the CRISPR-Cas adaptive immune system of certain bacteria. Cas9 is widely used as a genome editing tool due to its ability to introduce targeted double-stranded breaks in DNA.

Other names: Csn1Cas5Csx12

Mechanism of action

RNA-guided DNA cleavage

Biological functions

Bacterial adaptive immunityDNA cleavageGenome editing

Disease associations

Genetic Diseases (as a therapeutic target for correction)Infection (bacterial immunity role)

Safety considerations

Off-target effectsImmunogenicityDelivery challenges

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