CRK antisense RNA 1 (CRK-AS1)

CRK antisense RNA 1 (CRK-AS1) is a long noncoding RNA gene that functions as an antisense RNA, expressed from the opposite strand of the protein-coding CRK locus[1][7]. Antisense RNAs regulate gene expression through multiple mechanisms, including transcriptional interference, epigenetic modifications, and post-transcriptional RNA duplex formation[2][8]. These regulatory RNAs typically act in cis (at their site of synthesis) or trans (across different chromosomal loci), influencing their sense gene or nearby genomic regions[2]. While many antisense long noncoding RNAs have been implicated in various cancers and cellular processes such as proliferation and apoptosis[8], there is currently no direct evidence that CRK-AS1 itself serves as a therapeutic target or biomarker. Its biological significance remains an active area of research, especially in the context of epigenetic regulation and gene expression[1][2][8]. In summary, CRK-AS1 is a noncoding regulatory RNA, not a canonical receptor, enzyme, or therapeutic target, and is classified within the growing family of antisense long noncoding RNAs.

Other names

RP11-818O24.3CRK-AS1