Target intelligence / Profile preview

CROCC pseudogene 3

Molecular classification
Pseudogene, Long non-coding RNA (lncRNA)
01

Overview

CROCC pseudogene 3 (gene symbol: CROCCP3) is a human pseudogene related to the ciliary rootlet coiled-coil protein (Rootletin, CROCC), which is important for ciliary structure and centrosome cohesion in other functional paralogs. As a pseudogene, CROCCP3 does not encode a functional protein, but may play a role as a noncoding RNA in regulating gene expression, primarily by acting as a competing endogenous RNA (ceRNA) that interacts with microRNAs and modulates mRNA expression in cancer and possibly other biological contexts. Pseudogenes are increasingly recognized for their RNA-level regulatory functions and roles in disease biomarker discovery, but CROCC pseudogene 3 itself is not an established target for drug therapy or biomarker use. Its aliases include CROCCP3, KIAA1922, CROCCL2, and others. No evidence indicates involvement as a druggable protein target, and direct molecular functions remain largely uncharacterized.

Other names
CROCCP3KIAA1922CROCCL2Ciliary Rootlet Coiled-Coil, Rootletin Pseudogene 3Ciliary Rootlet Coiled-Coil, Rootletin-Like 2Putative Ciliary Rootlet Coiled-Coil Protein-Like 2 ProteinCiliary Rootlet Coiled-Coil Protein Pseudogene 3DJ798A10.2
02

Biological functions

Potential regulatory RNA (“ceRNA network”; may act as RNA sponge for miRNAs)Not known to encode functional protein or possess direct enzymatic, receptor, or transporter activities
03

Disease associations

Possible involvement in cancer via pseudogene-associated competitive endogenous RNA (ceRNA) network regulation (prognostic biomarker role identified for some pseudogenes, though direct roles for CROCC pseudogene 3 are unconfirmed)Other disease functions remain largely unexplored; pseudogenes as a class have emerging roles as noncoding RNA in disease
04

Biomarkers

Pseudogene expression profiles are emerging as biomarkers for cancer subtyping and prognostic evaluation in several types, but CROCC pseudogene 3 is not specifically cited as a clinical biomarker

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