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Target intelligence / Profile preview
Crooked neck pre-mRNA splicing factor 1 (CRNKL1)
- Target
- CRNKL1
- Molecular classification
- Other (splicing factor), Spliceosome component, Minor spliceosome (U12-type), RNA-binding protein
01
Overview
Crooked neck pre-mRNA splicing factor 1 (CRNKL1) is a ubiquitously expressed nuclear protein and a component of the spliceosome, essential for pre-mRNA splicing, particularly for U12-type introns. It functions as a nuclear retention factor to regulate the export of intron-retaining RNAs and is involved in the processing of HIV-1 unspliced RNAs, helping to control the cytoplasmic levels of both viral and cellular intron-containing transcripts. Loss or depletion of CRNKL1 leads to an increase in cytoplasmic levels of unspliced RNAs and influences genes involved in transcription, the cell cycle, and organelle organization. It has been associated with Fanconi anemia and may play roles in cancer and other diseases linked to splicing dysregulation[1][2][3][5][8].
- Other names
- Crooked neck-like protein 1CRNCGI-201MSTP021hCrnCLFSYF3Clf1Crooked neck homologSYF3 pre-mRNA-splicing factorHCRN
02
Biological functions
Pre-mRNA splicingRegulation of nuclear retention of intron-containing RNAsRNA processingCell cycle progression
03
Disease associations
Fanconi anemiaBasal cell carcinomaPossibly other cancer associations[5][4][6]
04
Safety considerations
Disruption may alter splicing regulation and nuclear retention of intron-containing RNAs, leading to dysregulation of gene expression and cell cycle processes[1][3]
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