Crotalinae snake venom toxin

Crotalinae snake venom toxins are a complex mixture of proteins and enzymes produced by snakes in the subfamily Crotalinae (pit vipers), such as rattlesnakes, cottonmouths, and copperheads. These mixtures are not a single molecular target, but rather contain diverse protein classes including neurotoxins, myotoxins, cytotoxins, hemotoxins, and enzymes like metalloproteinases and phospholipase A2, each acting via different pathological mechanisms including membrane disruption, tissue necrosis, coagulopathy, and modulation of ion channels. Rather than being a therapeutic drug target, these venoms are the cause of envenomation, and antivenoms (such as CroFab) are used to bind and neutralize the toxins, reducing morbidity and mortality. The entry "Venom toxins from Crotalinae snakes" does not refer to a specific drug target, but instead to a heterogenous mixture of toxins, so it should not be considered a defined molecular target for structured pharmaceutical targeting[1][2][3][5][6].

Other names

Crotalid venomPit viper venomRattlesnake venomCrotalinae pit viper toxins

Neutralization and clearance of venom toxins by antigen-binding fragments (Fab) of antibodies