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Target intelligence / Profile preview
CRTC3 antisense RNA 1 (CRTC3-AS1)
- Target
- CRTC3-AS1
- Molecular classification
- Non-coding RNA, Natural antisense transcript
01
Overview
CRTC3 antisense RNA 1 (CRTC3-AS1) is a long non-coding RNA transcribed antisense to the CRTC3 locus. Natural antisense RNAs such as this molecule are widespread. They typically function as regulatory elements in the genome, influencing the expression of their sense counterparts through mechanisms such as altering chromatin structure, inducing DNA methylation, modulating transcription rates, and influencing transcript stability and processing[1][2]. Antisense transcripts may locally affect promoter regions and gene expression without encoding a protein. While general biological roles for antisense RNAs include regulation of chromatin modification and RNA transcript dynamics, there is currently no evidence that CRTC3-AS1 is itself a direct therapeutic target or is implicated in specific diseases or drug interactions[3][2][1].
- Other names
- CRTC3-AS1antisense to CRTC3
02
Mechanism of action
RNA-directed modulation of transcription (epigenetic regulation via chromatin modification)\nPossible regulation of CRTC3 mRNA stability and processing
03
Biological functions
Regulation of transcriptionChromatin modificationPotential modulation of CRTC3 expression through antisense activities
04
Disease associations
Other (no specific disease associations reported for CRTC3-AS1; general roles for antisense RNAs include possible involvement in cancer, neurodegenerative, or other diseases depending on context, but no direct evidence for this locus)
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