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Cruzipain
- Molecular classification
- Enzyme, Cysteine protease, Papain-like cysteine protease
01
Overview
Cruzipain is a major cysteine protease and sulfated glycoprotein produced by the protozoan parasite *Trypanosoma cruzi*, the causative agent of Chagas disease. It is expressed in all developmental stages and strains of the parasite, playing essential roles in parasite virulence, host cell invasion, immune evasion, and tissue degradation. Due to its essential role for *T. cruzi* survival and pathogenesis—and absence from humans—cruzipain has been validated as an attractive target for drug development against Chagas disease. Multiple classes of cruzipain inhibitors have shown efficacy against *T. cruzi* both in vitro and in animal models.
- Other names
- CruzainGP57/51
02
Mechanism of action
Inhibition of cysteine protease activity, specifically Cruzipain
03
Biological functions
Host cell invasionImmune evasionParasite developmentTissue degradationProteolysis
04
Disease associations
Chagas diseaseInfectionVirulence
05
Safety considerations
Potential for off-target effects due to similarity to human cathepsinsImmunopathology related to sulfated epitopes
06
Interacting drugs
K11777
1 more in the full profile.
07
Biomarkers
Sulfated epitopes on cruzipain as indicators of infectionAntibody responses to cruzipain
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