Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Cryptosporidium phosphatidylinositol 4-kinase (CpPI(4)K)
- Target
- CpPI(4)K
- Molecular classification
- Enzyme, Lipid kinase
01
Overview
Cryptosporidium phosphatidylinositol 4-kinase (PI4K or CpPI(4)K) is a lipid kinase enzyme found in the protozoan parasite *Cryptosporidium*, which causes cryptosporidiosis. PI4K catalyzes the phosphorylation of phosphatidylinositol (PI) to generate phosphatidylinositol 4-phosphate (PI4P), a key lipid signaling molecule involved in various cellular processes. It is essential for parasite growth and survival within host cells, making it a validated drug target. Inhibitors targeting this kinase have shown potent anti-parasitic effects. CpPI(4)Ks differ structurally from their human counterparts enough to allow selective inhibition.
- Other names
- PI4KCryptosporidium PI4KCpPI(4)K
02
Mechanism of action
Competitive inhibition at the ATP-binding site
03
Biological functions
Phosphatidylinositol phosphorylationVesicle traffickingSignal transductionCytokinesisRegulation of parasite growthLipid signaling
04
Disease associations
Cryptosporidiosis pathogenesisParasite proliferation within host intestinal epithelial cells
05
Safety considerations
Potential off-target effects on human kinases (though selectivity has been observed)Resistance development
06
Interacting drugs
KDU731
2 more in the full profile.
Beyond the preview
Go deeper on Cryptosporidium phosphatidylinositol 4-kinase (CpPI(4)K).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Cryptosporidium phosphatidylinositol 4-kinase (CpPI(4)K).