Crystallin zeta pseudogene 2 (CRYZP2)

Crystallin zeta pseudogene 2 (CRYZP2) is classified as a pseudogene in the human genome, meaning it is a DNA sequence similar to that of a known gene (in this case, the CRYZ gene, which encodes crystallin zeta) but is generally non-functional—it does not produce an active protein product[4]. Pseudogenes like CRYZP2 typically arise from gene duplication or retrotransposition events and accumulate mutations that prevent expression or function. There is no evidence that CRYZP2 serves as a therapeutic target, is involved in disease, or produces a protein with biological activity. The functional, protein-coding version of this gene family, CRYZ, encodes a protein with NADPH-dependent quinone reductase activity, but this is not attributable to CRYZP2[2][4]. Key Context CRYZP2 is not an active gene and should not be considered a protein, enzyme, receptor, or other therapeutic target. Its presence in the genome is commonly referenced in genomic annotation but has no established role in health, disease, or drug interaction[4]. Information found pertains to the pseudogene only, not to the active gene CRYZ or its product.

Other names

NCBI Gene: 100526735Ensembl: ENSG00000250293HGNC: 49203