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Target intelligence / Profile preview
CSAG family member 3 (CSAG3)
- Target
- CSAG3
- Molecular classification
- Other (not classified as receptor, enzyme, transporter, or transcription factor)
01
Overview
CSAG family member 3 (CSAG3) is a protein-coding gene located on chromosome X, associated with drug resistance in cancer cells and the development of a neoplastic phenotype[1][2][7]. It functions in response to xenobiotic compounds and is not part of the major receptor, enzyme, or transporter families but is implicated in resistance to certain chemotherapies and tumor progression[1][3][7]. It is also known as a cancer/testis antigen and may be used as a biomarker for chemoresistance, though it is not considered a direct therapeutic target at this time[1][7].
- Other names
- CSAG3ACT24.2Chondrosarcoma-associated gene 2/3 proteinTRAG3TRAG-3Cancer/testis antigen 24.2Taxol-resistant-associated gene 3 proteintaxol resistance associated gene 3
02
Biological functions
Response to xenobiotic stimulusAssociated with drug resistanceNeoplastic (tumor) phenotype association
03
Disease associations
CancerLinked to chemoresistance (not a direct therapeutic target)
04
Safety considerations
Potential for tumor chemoresistance; clinical challenge in cancer treatment
05
Biomarkers
Potential marker for drug resistance or chemoresistance in cancer
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