Target intelligence / Profile preview

CsgA Protein (None)

Target: None
Molecular classification: Amyloid Fiber Subunit

Overview

CsgA is the major structural subunit of curli fibers, which are functional amyloid fibers produced by Escherichia coli and other enteric bacteria. Curli fibers are a primary component of the extracellular matrix in bacterial biofilms, contributing to cell adhesion, colonization, and resistance to antibiotics. CsgA is secreted as a soluble protein and assembles into amyloid fibrils on the cell surface, nucleated by CsgB. Targeting CsgA could disrupt biofilm formation and reduce bacterial virulence.

Other names: Major curlin subunit

Mechanism of action

Inhibition of CsgA polymerization or disruption of curli fiber formation

Biological functions

Biofilm FormationCell AdhesionExtracellular Matrix Production

Disease associations

InfectionBiofilm-associated InfectionsAntibiotic Resistance

Safety considerations

Potential for off-target effects on human amyloidogenic proteinsDevelopment of resistance mechanisms

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