CSL–NICD protein-protein interaction (CSL–NICD)

The CSL–NICD interaction is a central event in the canonical Notch signaling pathway, regulating gene expression critical for cell fate decisions. In the absence of NICD, CSL represses transcription. Upon Notch activation, NICD binds to CSL, displacing corepressors and recruiting coactivators (Mam/MAML) to activate transcription. This switch from repression to activation depends on whether corepressors or coactivators are bound to DNA-associated CSL. Recent studies indicate that released nuclear NICDs can transport or stabilize nuclear localization of free cytoplasmic pools of CLS/CSL proteins. The dynamic exchange between repressive/corepressor-bound versus activating/NICID-bound states underlies rapid responsiveness at target loci during developmental patterning or disease processes such as cancer progression or cardiac development/disorders.

Other names

CBF1/Su(H)/Lag-1 – RBPJ – Notch Intracellular DomainCBF1-NICDRBPJ-NICDSu(H)-NICDLag-1-NICD

Modulation of CSL-NICD interaction to alter transcription of Notch target genes