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CSL Transcription Factor Complex
- Molecular classification
- Transcription factor, DNA-binding protein, Protein complex
01
Overview
The CSL transcription factor complex is a key component of the Notch signaling pathway, acting as both a transcriptional activator and repressor. Its activity is modulated by interactions with coactivators (NICD/ICN and MAML) to activate transcription and corepressors (KyoT2, MINT/SHARP, Hairless, SMRT/N-CoR, and CIR) to repress transcription. CSL regulates genes involved in cell fate decisions, proliferation, and differentiation during development and adult tissue homeostasis.
- Other names
- CBF1RBP-JκSu(H)Lag-1
02
Mechanism of action
Modulation of CSL-mediated transcription (activation or repression) by targeting associated cofactors or the CSL protein itself.
03
Biological functions
Transcriptional regulationCell fate determinationCell differentiationCell proliferationDevelopmentNotch signaling pathway
04
Disease associations
CancerDevelopmental disordersImmune disorders
05
Safety considerations
Aberrant Notch signaling can lead to oncogenesis or developmental defects.
06
Biomarkers
HES1 expression levels as a downstream marker of Notch signaling activity
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