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CSMD2 antisense RNA 1 (CSMD2-AS1)
- Target
- CSMD2-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA
01
Overview
CSMD2 antisense RNA 1 (*CSMD2-AS1*) is a human long non-coding antisense RNA gene found on chromosome 1, transcribed from the opposite strand of the CSMD2 gene locus[1][2][4][7]. It does not code for a protein and is categorized as an antisense lncRNA, which means it can overlap or partially overlap exons of a coding gene on the anti-sense strand and may modulate gene expression through various mechanisms[5][6]. The gene has multiple transcript variants and alternative names, and while CSMD2-AS1 is not a classical drug target, its expression as part of a six-lncRNA signature has been correlated with overall prognosis in diffuse large B-cell lymphoma, suggesting a potential role in cancer biology as a prognostic biomarker[5]. There are currently no drugs, mechanisms of action, or therapeutic safety concerns associated with CSMD2-AS1, and its precise molecular function remains to be fully elucidated.
- Other names
- ENST00000434181ENST00000425631AL121980.1OTTHUMG00000013025RP5-1007G16.1NONHSAT002289
02
Biological functions
Modulation of gene expression (general for antisense lncRNAs)Possible role in cancer prognosis (DLBCL signature biomarker)
03
Disease associations
Cancer (specifically associated with prognosis in diffuse large B-cell lymphoma; potential implication in other malignancies has not been validated)
04
Biomarkers
Prognostic biomarker in diffuse large B-cell lymphoma (as part of a six-lncRNA panel)
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