CTAGE family member 4 (CTAGE4)

CTAGE family member 4 (CTAGE4) is a protein-coding gene expressed as a tumor-associated antigen, particularly in cutaneous T-cell lymphoma and several other tumor types[3][4]. It is predicted to participate in endoplasmic reticulum to Golgi vesicle-mediated transport and protein secretion and is likely localized to the membrane, particularly associated with the endoplasmic reticulum and exit sites[3]. CTAGE4 has limited normal tissue expression, restricted to testis and some tumors, and is notable for eliciting immune responses in patients with cutaneous T-cell lymphoma and melanoma[4]. Its functional role is not fully characterized, but its immunogenicity makes it a candidate biomarker and potential target for cancer immunotherapy[3][4].

Other names

cTAGE-4FLJ43692Cutaneous T-cell lymphoma-associated antigen 4Cutaneous-T-cell-lymphoma-specific tumor antigen 4Protein cTAGE-4

No specific drugs target CTAGE4, but potential immune mechanisms include T cell- or antibody-mediated recognition of CTAGE4-expressing tumor cells