Target intelligence / Profile preview

CTBP2 pseudogene 8 (CTBP2P8)

Target
CTBP2P8
Molecular classification
Transcriptional corepressor, Protein with oxidoreductase homology, Histone modification-associated protein
01

Overview

C-terminal binding protein 2 (CTBP2) is a transcriptional corepressor involved in gene repression through recruitment of chromatin-modifying enzymes. It forms complexes with DNA-binding proteins carrying the PIDLS motif and orchestrates removal or addition of histone marks to regulate gene activity. CTBP2 is expressed in various tissues and is implicated in cellular differentiation, development, and disease processes such as cancer and neurodevelopmental disorders. CTBP2 pseudogene 8 refers to a presumed non-functional genomic element; there is no evidence of protein-coding or therapeutic relevance for CTBP2P8. Researchers should refer to CTBP2 for meaningful biological or disease associated functions. CTBP2P8 (CTBP2 pseudogene 8) is not a validated target, is likely a mislabeling or artifact, and does not correspond to any protein, therapeutic target, or known biomarker. All functionally relevant information pertains to the canonical CTBP2, a transcriptional corepressor and scaffold involved in gene repression, with disease relevance in cancer and neurodevelopmental disorders.

Other names
C-terminal binding protein 2CTBP2RIBEYE
02

Mechanism of action

Not applicable—no drugs directly target CTBP2 or its pseudogenes.

03

Biological functions

Gene repression via chromatin modificationRecruitment of histone deacetylases, methylases/demethylasesScaffold protein for transcriptional complexesRegulation of cell differentiation
04

Disease associations

Cancer (associated with cancer development as part of corepressor complexes)Neurodevelopmental disordersCell survival and apoptosis (indirect regulation)Sex reversal syndromes

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