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Target intelligence / Profile preview
CTD small phosphatase-like protein (CTDSPL)
- Target
- CTDSPL
- Molecular classification
- Enzyme, Protein phosphatase
01
Overview
CTD small phosphatase
- Other names
- CTDSPLC3orf8HYA22PSR1RBSP3SCP3Small CTD phosphatase 3Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3RB protein serine phosphatase from chromosome 3Nuclear LIM interactor-interacting factor 1
02
Mechanism of action
Dephosphorylation of RNA polymerase II C-terminal domain (CTD), Negative regulation of transcriptional elongation
03
Biological functions
Regulation of transcription by RNA polymerase IINegative regulation of protein phosphorylationNegative regulation of RNA polymerase II transcriptionNeuronal gene silencing in non-neuronal cells
04
Disease associations
Cancer (notably non-small cell lung carcinoma)Schwannomatosis 1Schwannomatosis 2
05
Biomarkers
Biomarker for lung non-small cell carcinoma
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