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Target intelligence / Profile preview
CTP-choline-phosphate cytidylyltransferase (CCT)
- Target
- CCT
- Molecular classification
- Enzyme, Cytidylyltransferase
01
Overview
CTP-choline-phosphate cytidylyltransferase (CCT) is a key regulatory enzyme in phosphatidylcholine (PC) biosynthesis, catalyzing the rate-limiting step in the CDP-choline pathway. It exists as two main isoforms, alpha (PCYT1A) and beta (PCYT1B), with distinct localization and regulation. CCT activity is regulated by membrane binding, phosphorylation, and lipid activators. Dysregulation is linked to developmental disorders, liver steatosis, and dyslipidemia. Inhibitors like CT-2584 have shown anti-tumor effects.
- Other names
- Phosphorylcholine transferaseCDP-choline pyrophosphorylaseCDP-choline synthetaseCholine phosphate cytidylyltransferaseCTP-phosphocholine cytidylyltransferase
02
Mechanism of action
Inhibition of CTP-choline-phosphate cytidylyltransferase activity, leading to altered cellular lipid profiles and disruption of membrane integrity.
03
Biological functions
Phosphatidylcholine biosynthesisLipid metabolismMembrane biogenesisLipid homeostasis
04
Disease associations
Developmental disordersLiver steatosisDyslipidemiaCancer
05
Safety considerations
Potential disruption of membrane integrityAltered lipid metabolism
06
Interacting drugs
CT-2584
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