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Cubilin pseudogene 3 (CUBNP3)
- Target
- CUBNP3
- Molecular classification
- Other (Pseudogene)
01
Overview
Cubilin pseudogene 3 (CUBNP3) is a pseudogene—a non-functional DNA segment related to the cubilin gene (CUBN), typically generated by gene duplication or retrotransposition events leading to false or incomplete protein-coding potential. Unlike the functional cubilin gene, which encodes a large receptor for vitamin B12-intrinsic factor complexes and is relevant in renal and gastrointestinal physiology and disease, CUBNP3 does not produce a functional receptor or protein and thus does not serve as a pharmacological or biomarker target in disease[8][9]. If you seek information on the functional cubilin protein or gene (CUBN), more detail is available, as it is an endocytic epithelial receptor relevant to vitamin B12 absorption and kidney protein reabsorption[2][5][6][7]. However, **CUBNP3, the pseudogene, should not be mistaken for a functional therapeutic target or receptor**.
- Other names
- Cubilin (intrinsic factor-cobalamin receptor) pseudogene 3CUBNP3
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