CUE domain-containing protein 2 (CUEDC2)

CUE domain-containing protein 2 (CUEDC2) is an adaptor molecule encompassing a CUE domain that recognizes and binds ubiquitin, thereby participating in protein degradation and signaling pathway modulation[1][3][4][5]. CUEDC2 is expressed in multiple tissues and regulates diverse biological processes, including the cell cycle (by modulating the spindle assembly checkpoint and APC/C activity), inflammation (interacting with IKK complexes to inhibit NF-κB activity), hormone receptor signaling (regulating the degradation of estrogen and progesterone receptors, impacting sensitivity to endocrine therapies), and bone formation[1][2][3][4][5][6]. Loss or dysregulation of CUEDC2 has been associated with cancer progression in various tumor types; its role can be oncogenic or suppressive depending on cellular context[3][6]. CUEDC2 also acts as a modulator of the JAK-STAT pathway by stabilizing SOCS1, influencing leukemia pathogenesis[4]. Its multifunctional nature and regulatory influence on key signaling pathways mark it as an emerging therapeutic target and cancer biomarker.

Other names

CUEDC2CUE domain containing 2CUE domain-containing protein 2C10orf66HOYS6MGC2491bA18I14.5

Promotion of proteasomal degradation of hormone receptors (such as ERα and PR); Modulation of NF-κB pathway by inhibiting IKK activity; Suppression of JAK1-STAT3 signaling via stabilization of SOCS1; Alteration of cell cycle progression via APC/C activation and spindle checkpoint control