CUGBP Elav-like family member 2 (CELF2)

CUGBP Elav-like family member 2 (CELF2) is an RNA-binding protein involved in the regulation of pre-mRNA alternative splicing, mRNA stability, and translation. It is part of the CELF/BRUNOL protein family, characterized by multiple RNA recognition motifs. CELF2 plays central roles in tissue-specific alternative splicing, with crucial functions in heart, brain, and immune system development. Its dysregulation is associated with a range of diseases, including cancer—where it acts as a tumor suppressor—and developmental syndromes. CELF2 also mediates cellular responses to ionizing radiation in colorectal cancer, in part by promoting autophagy and potentiating radiation-induced cell death. Despite its relevance in disease processes, CELF2 itself is not typically considered a direct therapeutic target, but its expression level may serve as a useful biomarker and its modulation may provide new avenues for therapeutic intervention in cancer and possibly other disorders related to RNA processing abnormalities[1][2][3][4][5][6].

Other names

ETR-3BRUNOL3CUGBP2NAPORCELF-2CUG-BP2hNAPOREtr-3NAPOR-2Bruno-like protein 3CUG triplet repeat RNA-binding protein 2CUG-BP- and ETR-3-like factor 2ELAV-type RNA-binding protein 3Neuroblastoma apoptosis-related RNA-binding proteinRNA-binding protein BRUNOL-3DEE97

Not drug-targeted directly; modulation of CELF2 expression can increase autophagy, cell death, and alter mRNA splicing patterns in response to therapy (e.g., radiation therapy in colorectal cancer)[5]