CUGBP Elav-like family member 3 (CELF3)

CUGBP Elav-like family member 3 (CELF3) is an RNA-binding protein that regulates pre-mRNA alternative splicing, particularly by mediating tissue-specific and developmentally regulated inclusion or exclusion of exons during mRNA maturation. It binds to specific sequence motifs within pre-mRNA and can influence the splicing of key targets such as TNNT2 (encoding cardiac troponin T) and MAPT (encoding Tau protein), thereby impacting post-transcriptional gene expression. CELF3 is associated with certain neurodevelopmental disorders, including specific language impairment and reading disorder, but it is not currently classified as a direct therapeutic target or known to interact with approved drugs

Other names

BRUNOL1CAGH4ERDA4TNRC4Trinucleotide repeat-containing gene 4 proteinExpanded repeat domain protein CAG/CTG 4Expanded repeat domain, CAG/CTG 4Trinucleotide repeat containing 4CUG-BP- and ETR-3-like factor 3