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Target intelligence / Profile preview
Culture Filtrate Protein 10
- Molecular classification
- Protein, Secreted Antigen
01
Overview
Culture Filtrate Protein 10 (CFP-10) is a 10-kDa protein secreted by Mycobacterium tuberculosis. It forms a heterodimeric complex with ESAT-6, which is essential for M. tuberculosis virulence. CFP-10 is highly immunogenic, stimulating T cells and cytokine production, making it a target for diagnostic assays and vaccine development. Recent research shows CFP-10 triggers Ca²⁺ response in neutrophils, indicating proinflammatory activity.
- Other names
- CFP-10
02
Mechanism of action
CFP-10 forms a heterodimeric complex with ESAT-6, influencing virulence and immune response through neutrophil activation and cytokine release.
03
Biological functions
ImmunomodulationChaperone for ESAT-6Proinflammatory activityT cell stimulationCytokine production
04
Disease associations
TuberculosisInfection
05
Biomarkers
Diagnostic marker for TB infectionInterferon-gamma release assays
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