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Target intelligence / Profile preview
Culture Filtrate Protein 10 kDa (CFP10)
- Target
- CFP10
- Molecular classification
- ESAT-6-like proteins, Secreted protein
01
Overview
Culture filtrate protein 10 kDa (CFP10), also known as EsxB or Rv3874, is a secreted protein produced by Mycobacterium tuberculosis and related pathogenic mycobacteria. It plays a crucial role in the pathogenesis of tuberculosis and is a major target for immune recognition during infection. CFP10 forms a tight complex with ESAT-6 and is essential for virulence, facilitating bacterial escape from host immune responses. It is highly immunogenic, eliciting strong T cell responses and is used in diagnostic assays for TB infection.
- Other names
- EsxBRv3874
02
Biological functions
Modulation of host immunityInhibition of B cell functionsBacterial escape from host immune responsesVirulence factorT cell activation
03
Disease associations
TuberculosisInfection
04
Biomarkers
Diagnostic marker for M. tuberculosis infectionIndicator of latent or active TB infection
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