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Target intelligence / Profile preview
Cutaneous lymphocyte-associated antigen
- Molecular classification
- Carbohydrate epitope, Glycan, Post-translational modification
01
Overview
Cutaneous lymphocyte-associated antigen (CLA) is a specialized carbohydrate epitope expressed on the surface of certain T cells, particularly those involved in skin immunity. It serves as a key skin-homing receptor, enabling memory T cells to migrate specifically to cutaneous tissues. It acts as a ligand for E-selectin (CD62E), an adhesion molecule expressed by vascular endothelial cells at sites of inflammation in the skin.
02
Biological functions
Cell adhesionLymphocyte homingImmune cell traffickingT cell activation
03
Disease associations
PsoriasisAtopic dermatitisAllergic contact dermatitisDrug-induced rashes with eosinophilia/systemic symptoms (DRESS)Lichen planus variantsAlopecia areataCutaneous lymphoma
04
Biomarkers
Disease activity in inflammatory skin diseasesPresence of skin-homing T cells
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