Cutaneous microbiome composition

Cutaneous microbiome composition refers to the diverse and dynamic community of microorganisms—including bacteria (predominantly Actinobacteria, Firmicutes, Proteobacteria, and Bacteroidetes), fungi, viruses, archaea, and mites—that inhabit the skin. This composition varies by anatomical location, age, physiology, environmental exposure, and disease state[1][3][5][6]. The skin microbiome plays key roles in maintaining skin health by protecting against pathogens, modulating immune responses, producing nutrients, and regulating epidermal differentiation[1][3][6]. Disruptions in this community—termed dysbiosis—are linked to a range of skin diseases, including atopic dermatitis, psoriasis, and acne[3][4][2]. While the skin microbiome itself is not a molecular therapeutic target (such as a receptor or enzyme), it represents a complex ecological feature increasingly considered for interventional strategies, such as bacteriotherapy and probiotic-based treatments[4][8]. The concept of targeting the microbiome composition as a whole, rather than a single molecule, is still emerging and remains largely investigational[6][4].

Other names

skin microbiome compositionskin microbiota compositioncutaneous microbiota compositionskin microflora composition

Restoration or modulation of microbial balance Competitive exclusion of pathogens by commensals Induction of antimicrobial peptides and immune responses