Cutaneous structural and soluble proteins

Cutaneous structural and soluble proteins comprise a broad category of molecules essential for skin architecture and physiological function [StatPearls, 2023]. Structural proteins, including various keratins and filaggrin, form the physical barrier of the epidermis, while collagens and elastin provide tensile strength and elasticity to the dermis [PubMed, 2012]. Soluble proteins, such as cytokines, growth factors, and matrix metalloproteinases, regulate cellular communication, immune responses, and tissue remodeling [Journal of Investigative Dermatology, 2019]. In pathological states like psoriasis or atopic dermatitis, the balance and expression of these proteins are disrupted, leading to inflammation and barrier compromise [NIH, 2021]. While not a single therapeutic target, specific proteins within this group are the focus of numerous dermatological treatments, ranging from topical retinoids to systemic biological agents [PubChem, 2023].

Other names

Skin proteinsEpidermal and dermal proteinsIntegumentary proteins

Drugs targeting these proteins act through diverse mechanisms, including the modulation of gene expression to alter keratinocyte differentiation (e.g., retinoids), the enzymatic degradation of structural components (e.g., collagenase), and the neutralization of soluble inflammatory mediators like cytokines (e.g., monoclonal antibodies) [PubMed, 2020; PubChem, 2023].