Cutibacterium acnes cell-surface attachment protein DsA1 (DsA1)

The adhesion of *Cutibacterium acnes* (formerly *Propionibacterium acnes*) to human tissues is mediated by specific cell-surface proteins known as adhesins, notably DsA1, which recognize and bind to host molecules including dermatan sulfate and fibrinogen[3][5]. This process is critical for bacterial colonization, biofilm formation, and the pathogenesis of conditions such as acne vulgaris and device-associated infections[4][5]. The molecular characterization of DsA1 reveals a large glycosylated protein with diverse domains facilitating host interaction, including a signal peptide, LPXTG cell-wall anchoring motif, and repeat regions[3]. Inhibition of these adhesins is a potential avenue for preventing or treating infection and inflammation driven by *C. acnes*[5][3].

Other names

Propionibacterium acnes DsA1dermatan-sulfate adhesinPA25957 (gene locus)

Inhibition of bacterial binding to host tissue proteins (e.g., dermatan sulfate, fibrinogen). Blocking biofilm formation.