Cutibacterium acnes phylotype IA1

Cutibacterium acnes phylotype IA1 is the principal subgroup of this common, Gram-positive commensal skin bacterium. It is defined by genetic, proteomic, and phenotypic markers and is most strongly associated with the development and severity of acne vulgaris[2][3][4]. Phylotype IA1 exhibits distinct surface antigens, protein expression patterns, and inflammatory potential compared to other *C. acnes* phylotypes[2][3]. It is not a target in the molecular or pharmaceutical sense, but its identification can inform disease correlations and epidemiological studies[1][4]. The IA1 phylotype is routinely detected and distinguished via molecular methods (e.g., MLST, MALDI-MS) and is used in clinical microbiology for understanding strain-specific roles in skin health and disease[1][2][3][4].

Other names

IA1 phylotypeCutibacterium acnes type IA1Propionibacterium acnes phylotype IA1 (former genus name)C. acnes IA1

Inhibition of bacterial protein synthesis (for macrolides and lincosamides)\nInhibition of bacterial DNA gyrase/topoisomerase (for fluoroquinolones)