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Target intelligence / Profile preview
CX3C Chemokine Receptor 1 (CX3CR1)
- Target
- CX3CR1
- Molecular classification
- GPCR, Chemokine Receptor
01
Overview
CX3C chemokine receptor 1 (CX3CR1), also known as the fractalkine receptor or GPR13, is a transmembrane protein belonging to the G protein-coupled receptor (GPCR) family. Its primary endogenous ligand is fractalkine (CX3CL1), which exists in both membrane-bound and soluble forms. The interaction between CX3CL1 and CX3CR1 mediates cell adhesion, migration, and retention of leukocytes. It plays a key role in immune response, inflammation, cell adhesion, and chemotaxis and is associated with various diseases including neurodegenerative, inflammatory, cardiovascular diseases and cancer.
- Other names
- Fractalkine ReceptorGPR13G-protein coupled receptor 13
02
Mechanism of action
Modulates survival, migration, proliferation of target cells via intracellular signaling cascades after ligand binding.
03
Biological functions
Leukocyte migrationLeukocyte adhesionImmune regulationCNS microglial functionChemotaxisCell adhesionCell survivalSignal transduction
04
Disease associations
Neurodegenerative diseaseInflammationCancerCardiovascular diseaseInfectionAtherosclerosisMyocardial infarction
05
Safety considerations
HIV entry facilitation via coreceptor activity with CD4
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