CXADR pseudogene 3 (CXADRP3)

CXADR pseudogene 3 (CXADRP3) is a human pseudogene with sequence similarity to the CXADR gene, which encodes the Coxsackievirus and adenovirus receptor[1][5]. Pseudogenes like CXADRP3 are segments of DNA that resemble protein-coding genes but are generally viewed as non-functional; they typically arise from gene duplication or retrotransposition events and contain disabling mutations[1][5]. CXADRP3 does not encode a functional protein, is not known to function as a receptor, enzyme, transporter, or other molecular target, and is not a direct subject of drug interaction[1][5]. There is no established role for CXADRP3 in any canonical biological process or clinical condition. However, the broader class of pseudogenes, including other CXADR pseudogenes, has been shown to have diagnostic or regulatory potential in oncology research, as aberrant expression can sometimes distinguish cancer subtypes, though no such specific role is documented for CXADRP3[2]. CXADRP3 should not be confused with CXADR (Coxsackievirus and adenovirus receptor), which is a functional cell-surface receptor involved in viral entry, cell adhesion, and is a therapeutic target in virology and cardiology[3][4][6]. CXADRP3 is listed in major gene nomenclature databases as a validated human pseudogene at locus HGNC:33974[5]. If this query was intended to refer to the functional CXADR protein or receptor, the correct canonical form would be "Coxsackievirus and adenovirus receptor (CXADR)", not the pseudogene[3][4].