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Target intelligence / Profile preview
CXC chemokine receptor 3 (CXCR3)
- Target
- CXCR3
- Molecular classification
- G protein-coupled receptor (GPCR), CXC chemokine receptors
01
Overview
CXCR3 is a G protein-coupled receptor that belongs to the CXC chemokine receptor family. It is activated by the interferon-inducible chemokines CXCL9, CXCL10, and CXCL11. The primary role of CXCR3 is to regulate leukocyte trafficking, especially directing effector T cell migration toward sites of inflammation. It plays complex roles in cancer biology, with CXCR3-A promoting proliferation/migration and CXCR3-B inhibiting proliferation/migration.
- Other names
- G protein-coupled receptor 9 (GPR9)CD183
02
Biological functions
Immune cell traffickingLeukocyte traffickingSignal transductionCell migrationAdhesionCell proliferation
03
Disease associations
InflammationAutoimmunityCancerTissue repair
04
Safety considerations
Potential for dysregulation leading to autoimmune pathology
05
Biomarkers
CXCL10 levels (prognosis in cancer)
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