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Target intelligence / Profile preview
CXC chemokine receptor type 1 (CXCR1)
- Target
- CXCR1
- Molecular classification
- G-protein-coupled receptor
01
Overview
CXCR1 is a G-protein-coupled receptor that binds to the chemokine IL8/CXCL8 with high affinity, primarily expressed on neutrophils. It mediates neutrophil chemotaxis and activation, playing a critical role in inflammation and host defense. Aberrant CXCR1 expression is associated with cancer progression, making it a potential therapeutic target.
- Other names
- Interleukin 8 receptor alpha (IL8RA)CD181
02
Mechanism of action
Antagonism of CXCR1, blocking ligand binding and downstream signaling
03
Biological functions
Signal transductionNeutrophil chemotaxisImmune responseInflammationCell migrationCell activation
04
Disease associations
CancerInflammationImmune Disorders
05
Safety considerations
Potential for immunosuppressionOff-target effects on other chemokine receptors
06
Biomarkers
CXCR1 expression level in tumor cellsCXCR1 expression level in immune cells
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