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Target intelligence / Profile preview
CXC Chemokine Receptor Type 2 (CXCR2)
- Target
- CXCR2
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
CXCR2 (CXC chemokine receptor type 2) is a member of the G-protein-coupled receptor (GPCR) family that primarily functions as a receptor for several CXC chemokines, most notably interleukin-8 (IL-8, also known as CXCL8). It is highly expressed on neutrophils and oligodendrocyte lineage cells, and also found on basophils, T lymphocytes, and endothelial cells. CXCR2 plays critical roles in neutrophil biology (recruitment, homeostasis, aging), CNS development (OPC proliferation, migration, myelination), and angiogenesis. It has been implicated in acute lung injury, asthma, COPD, cancer, autoimmune diseases, and CNS disorders. SB225002 is a potent selective antagonist for research use.
- Other names
- Interleukin-8 receptor BIL-8 receptor BIL8RB
02
Mechanism of action
SB225002 is a potent selective antagonist that inhibits IL-8-induced calcium mobilization and prevents both *in vitro* chemotaxis/sequestration *in vivo*.
03
Biological functions
Neutrophil recruitmentNeutrophil homeostasisOligodendrocyte progenitor cell proliferationOligodendrocyte progenitor cell migrationOligodendrocyte progenitor cell maturationMyelinationAngiogenesisImmune responseCell migrationCell proliferationCell survivalInflammatory response mediationTumor microenvironment modulationCNS development/remyelinationAutoimmunity involvementCell signaling
04
Disease associations
Acute Lung Injury (ALI)AsthmaCOPDCancerAutoimmune diseasesMultiple sclerosisCentral Nervous System DisordersInflammation
05
Safety considerations
Excessive activation can lead to tissue damage due to over-recruitment of inflammatory cells such as neutrophils.
06
Interacting drugs
SB225002
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