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Target intelligence / Profile preview
CXXC-type zinc finger protein 5 (CXXC5)
- Target
- CXXC5
- Molecular classification
- Transcription factor
01
Overview
CXXC-type zinc finger protein 5 (CXXC5) is a transcription factor involved in various developmental processes, including myelopoiesis, endothelial differentiation, and oligodendrocyte differentiation. It acts as a negative regulator of the Wnt/β-catenin signaling pathway by interacting with Dishevelled (Dvl). Dysregulation of CXXC5 is associated with diseases like osteoporosis, alopecia, and impaired wound healing. It binds to unmethylated CpG dinucleotides via its CXXC domain, influencing epigenetic regulation. Recent studies implicate it in breast carcinogenesis.
- Other names
- CF5RINFWIDHSPC195
02
Mechanism of action
Negative regulation of Wnt/β-catenin signaling via Dvl binding; DNA binding to unmethylated CpG dinucleotides
03
Biological functions
MyelopoiesisEndothelial cell differentiationVessel formationOligodendrocyte differentiationRegulation of Wnt/β-catenin signaling
04
Disease associations
OsteoporosisAlopecia (hair loss)Impaired wound healingBreast cancer
05
Safety considerations
Cytosolic overexpression linked with pathological conditions
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