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Target intelligence / Profile preview
Cyclic Adenosine Monophosphate Signaling Pathway (cAMP Pathway)
- Target
- cAMP Pathway
- Molecular classification
- Signal Transduction Pathway
01
Overview
The cyclic adenosine monophosphate (cAMP) signaling pathway is a fundamental intracellular signal transduction mechanism that mediates the effects of numerous extracellular signals. cAMP acts as a second messenger and is crucial for regulating diverse physiological processes such as metabolism, gene expression, cell growth, immune responses, and vascular development. The pathway involves GPCRs, G proteins, adenylyl cyclase, phosphodiesterases, PKA, and Epac.
- Other names
- cAMP Signal Transduction PathwayCyclic AMP Pathway
02
Mechanism of action
N/A
03
Biological functions
Signal transductionMetabolism regulationGene expression controlImmune modulationVascular development
04
Disease associations
Metabolic disordersCardiovascular diseasesAutoimmune conditionsCancer
05
Safety considerations
Off-target effects of drugs targeting pathway componentsPotential for paradoxical effects due to complex feedback loopsVariability in pathway activity across different cell types and tissues
06
Interacting drugs
Phosphodiesterase inhibitors
2 more in the full profile.
07
Biomarkers
cAMP levelsPKA activityPhosphorylation status of downstream targets
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