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Target intelligence / Profile preview
Cyclic AMP-dependent Protein Kinase (PKA)
- Target
- PKA
- Molecular classification
- Enzyme, Serine/threonine kinase, Protein Kinase
01
Overview
Cyclic AMP-dependent protein kinase, commonly known as protein kinase A (PKA), is a serine/threonine-specific protein kinase whose activity is regulated by the cellular concentration of cyclic adenosine monophosphate (cAMP). PKA plays a central role in regulating various cellular processes, including: Glycogen metabolism, Sugar and lipid metabolism, Gene expression and regulation, Cell growth and differentiation. It acts as one of the primary effectors in the cAMP signaling pathway.
- Other names
- Protein kinase ASTK22PKA C
02
Mechanism of action
PKA's activity is modulated by cAMP binding, leading to the release of active catalytic subunits that phosphorylate downstream target proteins. Protein kinase inhibitors can also bind to free catalytic units to decrease their activity.
03
Biological functions
Signal transductionGlycogen metabolismSugar and lipid metabolismGene expression and regulationCell growth and differentiationPhosphorylation of target proteins
04
Disease associations
Metabolic disordersCancer
05
Safety considerations
Aberrant activity can contribute to diseases including metabolic disorders or certain cancers due to aberrant control over cell proliferation or apoptosis.
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