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Cyclic AMP Phosphodiesterase 3 (PDE3)
- Target
- PDE3
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
Cyclic AMP phosphodiesterase 3 (PDE3) is an enzyme that catalyzes the hydrolysis of cyclic adenosine monophosphate (cAMP) to adenosine 5'-monophosphate (AMP), thereby regulating intracellular cAMP levels. It plays a key role in cardiovascular physiology, modulating cardiac contractility and vascular smooth muscle tone. PDE3 exists as isoforms encoded by PDE3A and PDE3B. Selective PDE3 inhibitors like milrinone are used in the acute management of congestive heart failure, but chronic use has safety concerns.
- Other names
- cAMP-specific phosphodiesterasecAMP-specific PDE3',5'-cyclic-AMP 5'-nucleotidohydrolase
02
Mechanism of action
Inhibition of cAMP breakdown
03
Biological functions
Regulation of cAMP metabolismSignal transductionRegulation of cardiac contractilityRegulation of vascular smooth muscle tone
04
Disease associations
Cardiovascular diseaseHeart failure
05
Safety considerations
Increased mortality risk with chronic useArrhythmias
06
Interacting drugs
Milrinone
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