Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3)

Cyclic AMP-responsive element-binding protein 3-like protein 3 is a transcription factor of the basic leucine zipper family predominantly localized to the endoplasmic reticulum membrane. Upon ER stress or cyclic AMP stimulation, it undergoes regulated proteolysis, releasing an active fragment that translocates to the nucleus to control gene expression related to lipid and glucose metabolism, iron homeostasis, acute inflammatory response, and hepatic circadian regulation. It acts in concert with nuclear receptors and coactivators (such as PPARα) to promote fatty acid oxidation, ketogenesis, and expression of FGF21, thereby exerting systemic metabolic effects and mitigating insulin resistance and hypertriglyceridemia. CREB3L3 is implicated as a therapeutic target for metabolic disorders, including hyperlipidemia, diabetes, atherosclerosis, and hepatocellular carcinoma.

Other names

CREBHCREB-HHYST1481HYTG2cAMP responsive element binding protein 3 like 3Processed cyclic AMP-responsive element-binding protein 3-like protein 3cAMP-responsive element-binding protein, hepatic-specificCREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3

Transcriptional activation or inhibition of downstream metabolic and inflammatory genes, including synergy with ATF6 and PPARα