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Target intelligence / Profile preview
Cyclic GMP-AMP Synthase (cGAS)
- Target
- cGAS
- Molecular classification
- Enzyme, Nucleotidyltransferase, DNA Sensor
01
Overview
Cyclic GMP-AMP synthase (cGAS) is a cytosolic enzyme that functions as a key sensor of double-stranded DNA (dsDNA) in the innate immune system. Upon binding to dsDNA in the cytoplasm, cGAS catalyzes the synthesis of cyclic GMP-AMP (cGAMP), a secondary messenger that activates downstream immune signaling pathways. Dysregulation is linked to autoimmune diseases while targeted stimulation may be beneficial in immuno-oncology. Recent studies also show direct involvement in autophagy regulation.
- Other names
- Mb21d1
02
Mechanism of action
Modulation of cGAS activity (activation or inhibition)
03
Biological functions
Innate immunityDNA sensingActivation of STING signalingType I interferon productionAutophagy regulation
04
Disease associations
Autoimmune diseasesChronic inflammationCancerAge-related macular degenerationCellular senescenceDiabetes complicationsNeurodegenerative disorders
05
Safety considerations
Potential for off-target effects on immune systemRisk of exacerbating autoimmune diseases with activatorsPotential for immune suppression with inhibitors
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