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Cyclic GMP-AMP Synthase–Stimulator of Interferon Genes Pathway (cGAS-STING)
- Target
- cGAS-STING
- Molecular classification
- Signaling Pathway, Innate Immunity Pathway
01
Overview
The cGAS–STING pathway is a central component of the innate immune system, responsible for detecting cytosolic DNA from pathogens or damaged cells and initiating an immune response. This pathway plays a crucial role in antiviral defense, inflammation, and has implications in autoimmunity and cancer.
- Other names
- cGAS–STING PathwaycGAS/STING pathwaycGAS-STING signaling pathway
02
Mechanism of action
Agonists of STING as vaccine adjuvants or cancer immunotherapies; Antagonists/inhibitors of STING for treating autoimmune/autoinflammatory conditions.
03
Biological functions
Antiviral defenseInflammationAntitumor responsesImmune responseSignal transduction
04
Disease associations
Viral infectionsAutoimmune/autoinflammatory diseasesCancerMetabolic/inflammatory diseasesFibrotic diseases
05
Safety considerations
Overactivation can lead to autoimmune/autoinflammatory disordersViruses can evolve mechanisms to evade the pathway
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